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Pittsburgh head coach Mike Tomlin moved to 1-0 against the 49ers for his career with that 2007 outcome, while Harbaugh will be facing both the Steelers and Tomlin for the first time in his present position.

Even if Roethlisberger (3526 passing yards, 21 TD, 11 INT) does manage to play, the Steelers' offensive game plan will probably be altered somewhat because of his reduced mobility. Normally a team that likes to stretch the field with its pairing of fleet-footed wide receivers Mike Wallace (62 receptions, 1034 yards, 8 TD) and Brown (55 receptions, 925 yards, 2 TD), both of whom are averaging over 16 yards a catch this season, Pittsburgh may decide to lean more on running backs Rashard Mendenhall (710 rushing yards, 8 TD, 13 receptions) and Isaac Redman (353 rushing yards, 1 TD, 14 receptions) in this one. It's not the desired strategy, however, as lead back Mendenhall has had a disappointing year after posting career bests of 1,273 rushing yards and 13 touchdowns in 2010, having recorded just one 100-yard effort while working behind a shuffled front line that's dealt with injuries throughout the season. One of those occurred in the Cleveland game, with standout center Maurkice Pouncey incurring an ankle sprain of his own that his status up in the air as well for Monday. The 37- year-old Batch has attempted just 53 passes over the past three years, but did make a pair of starts in place of a suspended Roethlisberger last season and threw for three touchdowns in a win at Tampa Bay in one of those assignments.

Another reason why the Steelers may not want to go run-heavy is the strength of San Francisco's sturdy defense in that department. The 49ers have limited the opposition to a league-lows of 70.5 rushing yards per game and 3.2 yards per carry and have yet to give up a touchdown on the ground this season, while the team's string of 35 consecutive contests without permitting an individual 100- yard rusher is the third-longest in the NFL since 2000. The unit may not have its best stopper on Monday, though, with All-Pro inside linebacker Patrick Willis (93 tackles, 2 sacks, 1 INT) highly questionable with a hamstring strain that kept him out of last week's loss as well. The Niners were still able to hold Arizona to a mere 55 rushing yards on 23 totes with him out, with emerging star linebacker NaVorro Bowman (113 tackles) and rugged lineman Justin Smith (47 tackles, 6.5 sacks) leading the charge. Skelton came up with 282 passing yards and three touchdowns off the bench, however, with two of those scoring deliveries from 46 yards out or more. The secondary does contain two members with five interceptions each this year in cornerback Carlos Rogers (35 tackles, 15 PD) and free safety Dashon Goldson (54 tackles), while impressive rookie Aldon Smith (27 tackles, 10.5 sacks) and Ahmad Brooks (39 tackles, 6 sacks) offer two quality edge rushers from the outside linebacker positions.

Pittsburgh's tradition of excellent defense has continued during this 2011 season, and esteemed coordinator Dick LeBeau's group seems to have raised its play to an even higher level recently. The Steelers have allowed a scant 19 total points and only one touchdown over their last three wins and forced eight turnovers over that span, rectifying what had been a sore spot for the club early on this year. A secondary headlined by 2010 NFL Defensive Player of the Year Troy Polamalu (76 tackles, 1 sack, 1 INT), fellow safety Ryan Clark (86 tackles, 1 INT) and shutdown cornerback Ike Taylor (37 tackles, 2 INT, 11 PD) has been very stout, as Pittsburgh has surrendered the fewest passing yards (179.1 ypg) in the league despite both Woodley (37 tackles, 9 sacks, 1 INT) and Harrison missing extensive time. Woodley is due back this week from his hamstring injury and was on a roll prior to getting hurt in late October, racking up 7 1/2 sacks in just four games before being shelved, while second- year outside linebacker Jason Worilds (26 tackles, 3 sacks) is coming off a two-sack outburst against the Browns in his place. The Steelers have held their own against the run as well, with Polamalu, inside linebacker Lawrence Timmons (70 tackles, 1 INT) and unheralded end Brett Keisel (41 tackles, 3 sacks) spearheading a corps that's kept eight of 13 opponents under 100 rushing yards.

Without question, what will transpire at the quarterback position for Pittsburgh will have a big impact on the outcome of this game. Though Batch is serviceable and experienced, it would be a stretch to believe he'll be able to slice through a top-tier defense like San Francisco's without a hitch, and it's a must that the Steelers mount some semblance of a passing threat because the 49ers are so good against the run. Even at far less than 100 percent, Roethlisberger gives his team its best chance of winning, though Pittsburgh's explosiveness on offense may be reduced if his arm strength is affected by the injury.

The 49ers will likely encounter some difficulty running the ball on Monday, especially with Gore not having been in top form lately, so it's absolutely critical that the team protects Smith sufficiently. San Francisco's quarterback has been sacked five or more times in four games this season, and the Niners are 1-3 in those tilts. If Woodley does indeed make it back, Pittsburgh will have a pass rush to be reckoned with regardless of Harrison's absence.

OVERALL ANALYSIS

Sportsbook Betting Lines Predicted Outcome: Steelers 20, 49ers 16

Knox was taken off the field on a stretcher after taking a hard hit during Sunday's game against the Seattle Seahawks.

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